FMNL1 and PFN1

Number of citations of the paper that reports this interaction (PubMedID 10958683)
34

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		FMNL1	PFN1
Description		formin like 1	profilin 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Cortex Membrane Bleb Phagocytic Vesicle Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Molecular_function Protein Binding Small GTPase Binding GTPase Activating Protein Binding Actin Filament Binding	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding Cadherin Binding Proline-rich Region Binding
	Biological Process	Regulation Of Cell Shape Cell Migration Cortical Actin Cytoskeleton Organization Actin Filament Severing	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Regulation Of Catalytic Activity Protein Stabilization Negative Regulation Of Stress Fiber Assembly Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly
Pathways		RHO GTPases Activate Formins RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle	Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS		Asthma ( 31959851 31619474) Craniofacial microsomia ( 26853712) Hypothyroidism ( 30367059) Male-pattern baldness ( 28196072) Thyroid stimulating hormone levels ( 30367059)	Mean platelet volume ( 32888494)
Interacting Genes		11 interacting genes: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 SRPK2 TCERG1 TRIM54 XRCC6	33 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ
Entrez ID		752	5216
HPRD ID		06876	01452
Ensembl ID		ENSG00000184922	ENSG00000108518
Uniprot IDs		O95466	P07737
PDB IDs		4YDH	1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW
Enriched GO Terms of Interacting Partners?
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