WNT11 and KRTAP5-8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		WNT11	KRTAP5-8
Description		Wnt family member 11	keratin associated protein 5-8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix	Cytosol Keratin Filament
	Molecular Function	GTPase Activator Activity Frizzled Binding Cytokine Activity Protein Binding Protein Kinase Activator Activity	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Osteoblast Differentiation Epithelial To Mesenchymal Transition Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Atrial Septum Development Planar Cell Polarity Pathway Involved In Axis Elongation Protein Phosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Gene Expression Neuron Differentiation Bone Mineralization Negative Regulation Of Cell Growth Adrenal Gland Development Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Response To Nutrient Levels Activation Of Protein Kinase Activity Positive Regulation Of Transforming Growth Factor Beta2 Production Protein Localization To Cell Surface Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Cell Fate Commitment Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Artery Morphogenesis Positive Regulation Of Stress Fiber Assembly Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cloacal Septation Ventricular Septum Morphogenesis Lung-associated Mesenchyme Development Negative Regulation Of Cell Death Ureteric Bud Morphogenesis Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation Negative Regulation Of Cartilage Development Somite Development Neuroendocrine Cell Differentiation Secondary Palate Development Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production	Biological_process
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 30046033 32439900 20062060) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		17 interacting genes: CCNDBP1 CYSRT1 FUCA2 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-3 MDFI RASSF10	3 interacting genes: CRCT1 HHEX WNT11
Entrez ID		7481	57830
HPRD ID		04741	17252
Ensembl ID		ENSG00000085741	ENSG00000241233
Uniprot IDs		O96014	O75690
PDB IDs
Enriched GO Terms of Interacting Partners?
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