LAT2 and EIF4H

		LAT2	EIF4H
Description		linker for activation of T cells family member 2	eukaryotic translation initiation factor 4H
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Membrane Raft Extracellular Exosome	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding SH2 Domain Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding
	Biological Process	Adaptive Immune Response Calcium-mediated Signaling Intracellular Signal Transduction B Cell Activation Mast Cell Degranulation B Cell Receptor Signaling Pathway	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways		Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 29848360)
Interacting Genes		8 interacting genes: CBL EIF4H GAB1 GRB2 PLCG1 PLCG2 SOS1 UBQLN4	12 interacting genes: C11orf68 CCL24 DDIT4L DLG3 FBXO17 LAT2 LNX1 PICK1 PTPN12 RFC2 SPG21 STT3B
Entrez ID		7462	7458
HPRD ID		09304	11940
Ensembl ID		ENSG00000086730	ENSG00000106682
Uniprot IDs		Q9GZY6	Q15056
PDB IDs		3MAZ
Enriched GO Terms of Interacting Partners?
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