UMPS and ZNF227

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		UMPS	ZNF227
Description		uridine monophosphate synthetase	zinc finger protein 227
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus
	Molecular Function	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Nucleoside Metabolic Process Pyrimidine Nucleobase Biosynthetic Process 'de Novo' UMP Biosynthetic Process Cellular Response To Xenobiotic Stimulus	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Pyrimidine biosynthesis	Generic Transcription Pathway
Drugs		6-hydroxyuridine-5'-phosphate
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Plateletcrit ( 32888494) Serum metabolite levels ( 33031748)
Interacting Genes		16 interacting genes: A2M CALU CASP8 CDC42EP3 DLST NOS3 OGT PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 SUMO2 ZNF227	6 interacting genes: CDKN2A CEP70 CSNK1E GSK3B RPS6KA6 UMPS
Entrez ID		7372	7770
HPRD ID		02022	15752
Ensembl ID		ENSG00000114491	ENSG00000131115
Uniprot IDs		A8K5J1 P11172	B7Z6M2 Q658S5 Q86WZ6
PDB IDs		2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
Enriched GO Terms of Interacting Partners?
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