UBE2V1 and SHISA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UBE2V1	SHISA4
Description		ubiquitin conjugating enzyme E2 V1	shisa family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex Protein-containing Complex UBC13-UEV1A Complex Extracellular Exosome	Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Body mass index ( 29273807) Daytime nap ( 33568662) Depression ( 33859377) Depressive symptom (fatigue) (ordinal trait) ( 31530331) Depressive symptom (low self-esteem) (ordinal trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698)
Interacting Genes		48 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN PSMD14 RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1 ZNRF2	10 interacting genes: CHRM2 CNIH1 CYBC1 DESI1 MAL PDCD6 SGTA TSPAN33 UBE2V1 UPK1B
Entrez ID		7335	149345
HPRD ID		04294	12729
Ensembl ID		ENSG00000244687	ENSG00000198892
Uniprot IDs		G3V2F7 Q13404	Q96DD7
PDB IDs		2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?
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