UBE2L3 and HECTD4

  • Number of citations of the paper that reports this interaction (PubMedID 29643511)
  • 50

UBE2L3

HECTD4

Description ubiquitin conjugating enzyme E2 L3 HECT domain E3 ubiquitin protein ligase 4
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alcohol consumption (max-drinks) ( 29460428)
  • Alcohol dependence symptom count ( 29460428)
  • Body mass index ( 26426971 28892062)
  • Celiac disease and Rheumatoid arthritis ( 26546613)
  • Coffee consumption ( 29367735)
  • Diastolic blood pressure ( 27736895)
  • Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Fish consumption ( 32895509)
  • Granulocyte count ( 27863252)
  • HDL cholesterol levels ( 28334899 31087446)
  • Hematological and biochemical traits ( 31902109)
  • High density lipoprotein cholesterol levels ( 30718733)
  • High light scatter reticulocyte count ( 32888494)
  • High light scatter reticulocyte percentage of red cells ( 32888494)
  • Hip circumference adjusted for BMI ( 34021172)
  • Hypertension ( 32709000)
  • Immature fraction of reticulocytes ( 32888494)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Mean corpuscular hemoglobin concentration ( 32888494)
  • Mean spheric corpuscular volume ( 32888494)
  • Metabolic syndrome ( 30382898)
  • Myeloid white cell count ( 27863252)
  • Myocardial infarction ( 30226566)
  • Neutrophil count ( 27863252)
  • Reaction time ( 29844566)
  • Red cell distribution width ( 32888494)
  • Response to alcohol consumption (flushing response) ( 29460428)
  • Reticulocyte count ( 32888494)
  • Reticulocyte fraction of red cells ( 32888494)
  • Serum uric acid levels ( 29124443 32514006)
  • Sum basophil neutrophil counts ( 27863252)
  • Sum neutrophil eosinophil counts ( 27863252)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Tea consumption ( 33080986)
  • Thoracic-to-hip circumference ratio ( 26675016)
  • Type 2 diabetes ( 32499647)
  • Urate levels ( 31578528)
  • Weight ( 34054925)
  • White blood cell count ( 27863252)
Interacting Genes 109 interacting genes: ANKIB1 AREL1 ARIH1 ARIH2 ATXN3 BRAP BRCA1 CBL CBLB CBLC CCNB1IP1 CDC42 CDKN1B CUL9 DTX3 FBXO2 FOS HACE1 HECTD1 HECTD2 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC3 HERC4 HERC6 HSPA4 HUWE1 IRF2BP1 ITCH LIG4 LTN1 MAPK6 MDM2 MEX3A MEX3C MID1 MKRN2 MKRN3 MUL1 MYCBP2 NEDD4 NEDD4L NFKBIA NR3C1 OTUB1 OTUD3 PIAS1 PIAS2 PJA1 POLR2A PRKN PTEN RBCK1 RBX1 RC3H1 RELA RNF103 RNF113B RNF114 RNF125 RNF14 RNF144A RNF144B RNF150 RNF168 RNF170 RNF182 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF31 RNF7 RTF2 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TP53 TRAF6 TRAF7 TRIM21 TRIM23 TRIM25 TRIM28 TRIM31 TRIM39 TRIM55 TRIP12 UBA1 UBA5 UBA6 UBA7 UBASH3A UBE3A UBE3C UBOX5 UBR4 UBR5 VPS11 WWP1 WWP2 2 interacting genes: UBE2D2 UBE2L3
Entrez ID 7332 283450
HPRD ID 04762 08170
Ensembl ID ENSG00000185651 ENSG00000173064
Uniprot IDs A0A024R1A4 P68036 F8VWT9
PDB IDs 1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13 6XXU 7B5L 7B5N
Enriched GO Terms of Interacting Partners?
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