TYR and TYRP1

Number of citations of the paper that reports this interaction (PubMedID 14623273)
6

Data Source:
HPRD (in vivo)

		TYR	TYRP1
Description		tyrosinase	tyrosinase related protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi-associated Vesicle Cytosol Integral Component Of Membrane Melanosome Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytoplasm Endosome Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle
	Molecular Function	Tyrosinase Activity Copper Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity	Tyrosinase Activity Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Population Proliferation Response To UV Response To Blue Light Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP	Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Positive Regulation Of Melanin Biosynthetic Process
Pathways		Melanin biosynthesis	Melanin biosynthesis
Drugs		NADH Azelaic acid Monobenzone Mimosine Hydroquinone Arbutin Hexylresorcinol
Diseases
GWAS		Age-related macular degeneration ( 23326517) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Basal cell carcinoma ( 31174203 33549134 27539887) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 17952075) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eye color ( 20585627 33692100) Eye color (brightness) ( 30664655) Fish- and plant-related diet ( 32066663) Freckles ( 17952075) Hair color ( 30664655 29662168 26926045) Intraocular pressure ( 29617998) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Macular thickness ( 30535121) Melanoma ( 21983787 28212542 24980573 19578364) Neurociticism ( 29500382) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-melanoma skin cancer ( 29739929) Optic disc size ( 31809533) Skin pigmentation ( 31315583 30664655 17999355) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 20410501 27723757 22561518)	Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 18488028) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eye color ( 23548203 33692100 30664655) Eye color (brightness) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 30166351) Hair color ( 22556244 29662168) Low tan response ( 29739929) Metabolite levels ( 23823483) Mild to moderate chronic kidney disease ( 31178898) Mitochondrial DNA copy number ( 30704525) Neuroticism ( 27089181) Nevus count or cutaneous melanoma ( 32341527) Psoriasis ( 30921485) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Skin pigmentation ( 29195075) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		3 interacting genes: PRICKLE1 TYRP1 UBASH3A	3 interacting genes: GIPC1 SEC22A TYR
Entrez ID		7299	7306
HPRD ID		06086	00283
Ensembl ID		ENSG00000077498	ENSG00000107165
Uniprot IDs		L8B082 P14679	P17643
PDB IDs			5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T
Enriched GO Terms of Interacting Partners?
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