TYMS and THOC1

		TYMS	THOC1
Description		thymidylate synthetase	THO complex 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Thymidylate Synthase Activity Folic Acid Binding Protein Homodimerization Activity Sequence-specific MRNA Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	DTMP Biosynthetic Process DTTP Biosynthetic Process Aging Circadian Rhythm Response To Xenobiotic Stimulus Response To Toxic Substance Negative Regulation Of Translation Uracil Metabolic Process Methylation Response To Progesterone Response To Vitamin A Response To Cytokine Tetrahydrofolate Interconversion Response To Ethanol Response To Organophosphorus Developmental Growth Cartilage Development Response To Glucocorticoid Response To Folic Acid Intestinal Epithelial Cell Maturation DNA Biosynthetic Process Liver Regeneration	Regulation Of DNA Recombination RNA Processing MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Raltitrexed Floxuridine Trifluridine Gemcitabine Fluorouracil Methotrexate Pemetrexed Capecitabine Thymidine monophosphate 10-Propargyl-5,8-Dideazafolic Acid Deoxyuridine monophosphate S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 2,4-Diamino-5-phenyl-6-ethylpyrimidine N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE Tegafur Tegafur-uracil
Diseases
GWAS		Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: CDC42 EPB41L3 ITGAM NAPG NDUFV2 OCRL SH3GL2 SMCHD1 TAF3 THOC1 UPF2 YES1	28 interacting genes: AGR2 AKAP9 ATP1B1 BHLHB9 CTAG1A CTAG1B DHX8 EXOC5 FRA10AC1 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C RABGEF1 RB1 REL SAP30BP SF3B2 TADA2A TRIM27 TRIM54 TYMS USHBP1 WDR77 ZMYND12
Entrez ID		7298	9984
HPRD ID		01774	09498
Ensembl ID		ENSG00000176890	ENSG00000079134
Uniprot IDs		P04818 Q53Y97	Q96FV9
PDB IDs		1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E	1WXP 7APK
Enriched GO Terms of Interacting Partners?
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