C5AR1 and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 17322907)
87

Data Source:
HPRD (in vitro, in vivo)

		C5AR1	C5AR2
Description		complement C5a receptor 1	complement C5a receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Secretory Granule Membrane Apical Part Of Cell	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Complement Component C5a Binding Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Proliferation In Hindbrain Neutrophil Chemotaxis Animal Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization Regulation Of Tau-protein Kinase Activity	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Chronic periodontitis ( 25008200)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS	17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		728	27202
HPRD ID		00224	17072
Ensembl ID		ENSG00000197405	ENSG00000134830
Uniprot IDs		P21730	Q9P296
PDB IDs		5O9H 6C1Q 6C1R
Enriched GO Terms of Interacting Partners?
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