BHLHA9 and POMC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BHLHA9	POMC
Description		basic helix-loop-helix family member a9	proopiomelanocortin
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Heterodimerization Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Developmental Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion
Pathways			Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production
Drugs			Loperamide Etorphine Dihydromorphine
Diseases
GWAS			Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		12 interacting genes: BCL2L2 GOLGA6L9 KIAA0753 KRT31 MCRS1 NECAB1 POMC PPP1R12C RNF125 SAT1 STK16 TFIP11	28 interacting genes: ABI2 APP ATP6V0D2 BHLHA9 C1orf109 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN
Entrez ID		727857	5443
HPRD ID			01462
Ensembl ID		ENSG00000205899	ENSG00000115138
Uniprot IDs		Q7RTU4	P01189
PDB IDs			4XNH 4XPD 4Y49 6TUB
Enriched GO Terms of Interacting Partners?
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