TNNC1 and MST1

Number of citations of the paper that reports this interaction (PubMedID 18986304)
21

Data Source:
BioGRID (enzymatic study)

		TNNC1	MST1
Description		troponin C1, slow skeletal and cardiac type	macrophage stimulating 1
Image
GO Annotations	Cellular Component	Cytosol Troponin Complex Cardiac Troponin Complex	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding	Endopeptidase Activity Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Diaphragm Contraction Skeletal Muscle Contraction Regulation Of Muscle Contraction Response To Metal Ion Transition Between Fast And Slow Fiber Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Proteolysis Histone H2A-S139 Phosphorylation Negative Regulation Of Gluconeogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Striated Muscle Contraction	Signaling by MST1
Drugs		Trifluoperazine Levosimendan Felodipine Bepridil Calcium Aluminium monostearate 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling worry ( 29500382) Schizophrenia ( 23974872) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 28067908 23128233) Primary sclerosing cholangitis ( 23603763 27992413 21151127) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 19915572 28067908 20228799 25082827 21297633)
Interacting Genes		13 interacting genes: CDK1 MST1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TOPAZ1 TRIM63 UBE2C	10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2
Entrez ID		7134	4485
HPRD ID		08930	00798
Ensembl ID		ENSG00000114854	ENSG00000173531
Uniprot IDs		P63316 Q6FH91	G3XAK1 P26927 Q53GN8
PDB IDs		1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 2MKP 2MLE 2MLF 2MZP 2N79 2N7L 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI	2ASU 4QT8
Enriched GO Terms of Interacting Partners?
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