TNFAIP3 and TAX1BP1

Number of citations of the paper that reports this interaction (PubMedID 10435631)
49

Data Source:
HPRD (in vivo, two hybrid)

		TNFAIP3	TAX1BP1
Description		TNF alpha induced protein 3	Tax1 binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Extracellular Exosome	Cytosol Extracellular Exosome
	Molecular Function	Protease Binding DNA Binding Ubiquitin-protein Transferase Activity Thiol-dependent Deubiquitinase Protein Binding Protein C-terminus Binding Zinc Ion Binding Kinase Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Lys63-specific Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Kinase Binding Metal Ion Binding
	Biological Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Apoptotic Process Inflammatory Response Cytoskeleton Organization Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process Protein K33-linked Deubiquitination Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process	Apoptotic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling	Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Cardiac Troponin-T levels ( 23247143) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Malaria ( 31844061) Multiple sclerosis ( 24076602) Phosphatidylcholine-ether levels ( 31551469) Primary biliary cholangitis ( 26394269) Psoriasis ( 25903422 20953190 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 24449572 32723749 30423114 23143596 24390342 20453841 20453842 17982456) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097066 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 28314753) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Tonsillectomy ( 27182965 28928442) Type 1 diabetes ( 34127860)	Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)
Interacting Genes		47 interacting genes: ARRDC3 CCDC50 CHUK EAPP GAS8 GIT2 GSK3B IKBKB IKBKG LAPTM5 LNX1 MAP3K5 OCLN PFKL PIBF1 RAD23A RBCK1 RIPK1 RLIM RNF11 RNF14 RNF168 RNF216 RNF5 SNAI1 TAX1BP1 TICAM1 TNIP1 TNIP2 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5	76 interacting genes: ARHGAP1 AZI2 C18orf25 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN EMILIN1 FAM161A FAM168A FAM189A2 FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LGALS8 LITAF LMO3 LNX1 LRATD2 MAP1LC3B MAP1LC3C MRPL11 MRPL53 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RB1CC1 RIPK1 RNF11 SCNM1 SERPINB7 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP1 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446
Entrez ID		7128	8887
HPRD ID		01857	05618
Ensembl ID		ENSG00000118503	ENSG00000106052
Uniprot IDs		P21580	B4DSG5 Q86VP1
PDB IDs		2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 5LRX 5V3B 5V3P	2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G
Enriched GO Terms of Interacting Partners?
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