C1QA and C1R

Number of citations of the paper that reports this interaction (PubMedID 10878362)
17

Data Source:
HPRD (in vitro)

		C1QA	C1R
Description		complement C1q A chain	complement C1r
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Synapse Collagen-containing Extracellular Matrix Postsynapse	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Amyloid-beta Binding Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Microglial Cell Activation Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Aging Response To Iron Ion Neuron Remodeling Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death	Immune Response Complement Activation, Classical Pathway Zymogen Activation Innate Immune Response
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab	Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Inflammatory biomarkers (multivariate analysis) ( 33110245)
Interacting Genes		29 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 RHOA SGTA SGTB SLC25A47 UBQLN1 UBQLN2	8 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1 TUBGCP2
Entrez ID		712	715
HPRD ID		00393	01954
Ensembl ID		ENSG00000173372	ENSG00000159403
Uniprot IDs		A0A024RAG6 P02745	P00736
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V	1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39
Enriched GO Terms of Interacting Partners?
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