TIAM1 and GART

		TIAM1	GART
Description		TIAM Rac1 associated GEF 1	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Image
GO Annotations	Cellular Component	Nucleus Cytosol Microtubule Plasma Membrane Cell-cell Junction Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuronal Cell Body Dendritic Spine Cell-cell Contact Zone Axonal Growth Cone Main Axon Synapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Cytosol Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Lipid Binding Kinase Binding Receptor Tyrosine Kinase Binding	Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity ATP Binding Metal Ion Binding
	Biological Process	Cardiac Muscle Hypertrophy Apoptotic Process Cell-matrix Adhesion Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Protein Binding Cellular Protein-containing Complex Assembly Response To Cocaine Positive Regulation Of JUN Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Activation Of GTPase Activity NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Schwann Cell Chemotaxis Regulation Of Dopaminergic Neuron Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Neuron Projection Extension Regulation Of Non-canonical Wnt Signaling Pathway	Brainstem Development Purine Nucleotide Biosynthetic Process 'de Novo' IMP Biosynthetic Process Glycine Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Organic Substance Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Adenine Biosynthetic Process Tetrahydrofolate Biosynthetic Process
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5	Purine ribonucleoside monophosphate biosynthesis
Drugs			Pemetrexed Glycinamide Ribonucleotide N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acid
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)	Crohn's disease ( 23128233) Educational attainment ( 25201988) Psoriasis ( 25854761)
Interacting Genes		35 interacting genes: ABCA1 ANK1 BTRC CAMK2G CD44 CDC42 CREBBP CSNK1A1 EFNB1 EPHA2 FNDC3B GART HRAS MAPK8IP1 MAPK8IP2 MYC NME1 OSBPL1A PARD3 PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAC1 RHOA SRC SRSF5 SYCP1 UBC YWHAG ZKSCAN4	10 interacting genes: CDC42 IFNAR1 JUN KPNA2 NMI OGT PXN TIAM1 TMPRSS15 TRAF6
Entrez ID		7074	2618
HPRD ID		02820	00716
Ensembl ID		ENSG00000156299	ENSG00000159131
Uniprot IDs		A0A2X0TW27 Q13009	P22102 Q59HH3
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 2QK4 2V9Y 4EW1 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2 4ZZ3 5J9F
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?