THBD and PROC

Number of citations of the paper that reports this interaction (PubMedID 11106601)
13

Data Source:
HPRD (in vitro)

		THBD	PROC
Description		thrombomodulin	protein C, inactivator of coagulation factors Va and VIIIa
Image
GO Annotations	Cellular Component	Extracellular Space Vacuolar Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Apicolateral Plasma Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To CAMP Negative Regulation Of Fibrinolysis	Proteolysis Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Drotrecogin alfa Ibuprofen Dexibuprofen	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Lung function (FVC) in asthma ( 32989782) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)	Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)
Interacting Genes		31 interacting genes: AIG1 APOC2 APOC4 AQP6 CD79A CIDEB CYBC1 EBP ERGIC3 F2 FAM209A FCER1G GPX8 KIR2DL3 LMNA MMGT1 MTIF3 MUC1 PDZK1IP1 PF4 PHF24 PROC PSENEN RHBDD2 SERPINA5 SLC19A3 SLC35C2 TMEM14B TMEM35A TMEM86B TMX2	17 interacting genes: CFLAR CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 NGLY1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		7056	5624
HPRD ID		01764	01466
Ensembl ID		ENSG00000178726	ENSG00000115718
Uniprot IDs		P07204	P04070
PDB IDs		1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3	1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C
Enriched GO Terms of Interacting Partners?
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