TFDP1 and SERTAD2

Number of citations of the paper that reports this interaction (PubMedID 11331592)
39

Data Source:
HPRD (in vitro)

		TFDP1	SERTAD2
Description		transcription factor Dp-1	SERTA domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding	Transcription Coactivator Activity Protein Binding Transcription Regulator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Cycle Epidermis Development Anoikis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Fat Cell Proliferation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process	Negative Regulation Of Cell Growth Chromatin-mediated Maintenance Of Transcription
Pathways		Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria G0 and Early G1 Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Height ( 31562340) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mild influenza (H1N1) infection ( 26379185)	Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) TPE interval (resting) ( 32386560) Visceral fat ( 22589738)
Interacting Genes		18 interacting genes: CDK1 CDK2 CDK6 CDKN2A CREBBP E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 NPDC1 OGT SERTAD2 SIAH1 SOCS3 TP53 TP53BP1	28 interacting genes: AP2B1 ATG12 C1orf109 CDC7 CEP68 CKS1B CREBBP CTNNA3 E2F1 ESPNL HELLS IGFN1 KAT2B KAT5 PARVG PIK3R3 PLA2G6 PRKAB2 REL STRA8 SUPT7L TFDP1 TNS2 TRIM28 XPO1 ZNF524 ZNF581 ZSCAN22
Entrez ID		7027	9792
HPRD ID		01792	18040
Ensembl ID		ENSG00000198176	ENSG00000179833
Uniprot IDs		A0A024RDY4 Q14186	Q14140
PDB IDs		2AZE 5GOW 5TUU 5TUV
Enriched GO Terms of Interacting Partners?
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