TCOF1 and UBTF

Number of citations of the paper that reports this interaction (PubMedID 15249688)
103

Data Source:
HPRD (in vivo, two hybrid)

		TCOF1	UBTF
Description		treacle ribosome biogenesis factor 1	upstream binding transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytosol	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Binding Transporter Activity Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Scaffold Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways			NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) hemolysis of donated blood (osmotic) ( 34014839) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		9 interacting genes: CSNK2A1 CSNK2A2 NOP56 PCNA SPOP SRPK2 TM9SF1 UBC UBTF	34 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 EP300 GSK3A IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2
Entrez ID		6949	7343
HPRD ID		06026	02814
Ensembl ID		ENSG00000070814	ENSG00000108312
Uniprot IDs		B4DRA2 E7ETY2 H0Y8Y7 Q13428	P17480
PDB IDs			1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
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