TCF7L2 and TRAF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TCF7L2	TRAF1
Description		transcription factor 7 like 2	TNF receptor associated factor 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Beta-catenin-TCF Complex	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Plasma Membrane Signaling Receptor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Nuclear Receptor Binding Protein Kinase Binding Sequence-specific DNA Binding Gamma-catenin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Armadillo Repeat Domain Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Pancreas Development Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Regulation Of Hormone Metabolic Process Glucose Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Myoblast Fate Commitment Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Protein K63-linked Ubiquitination Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Signaling by TCF7L2 mutants Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder (body mass index interaction) ( 24322204) Blood glucose levels ( 29615537 31928498) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 29381148 26426971 31453325 28892062 25673413 28448500) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 27117709) Breast Cancer in BRCA1 mutation carriers ( 23544013) Childhood onset type 2 diabetes ( 33479058) Circulating leptin levels or type 2 diabetes ( 32341051) Clinical laboratory measurements ( 27897004) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 30529582 24836286 29471430) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Fasting insulin ( 33402679 34059833) Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138) Glycated hemoglobin levels ( 20849430 34059833 28898252) Glycemic traits (pleiotropy) ( 31021400) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte count ( 32888494) High myopia ( 31816047) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertrophic cardiomyopathy ( 33495597) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Ischemic stroke ( 26732560) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myopia ( 27182965) Offspring birth weight ( 31043758) Peak insulin response ( 28490609) Peripheral artery disease ( 31285632) Proinsulin levels ( 21873549) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Retinopathy x type 2 diabetes interaction ( 32541925) Schizophrenia vs type 2 diabetes ( 30470734) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878 30578418) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 27189021 17668382 22885922 18372903 24509480 17293876 30054458 30470734 22693455 26961502 31324766 29358691 25102180 30297969 19734900 28254843 25483131 17554300 26818947 31049640 23945395 31118516 23300278 32499647 20581827 19401414 24390345 17463246 30718926 17463248 17463249 22101970 21347282 28869590 17460697 19056611 23209189) Urate levels ( 31578528) Waist circumference ( 25673412) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24782177 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) White blood cell count ( 32888494)
Interacting Genes		47 interacting genes: AR BPIFA1 C19orf54 CCNG2 CNFN CRX CSNK2A1 CSNK2A2 CTNNB1 CTNNBIP1 CYSRT1 DAXX DAZAP2 EP300 FAM168B FBLN1 HIC1 INTS11 JUP KCNE4 KMT5A KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 MEN1 MSX2 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSMA3 RBPMS RNF138 SMUG1 TLE3 TLE5 TRAF1 TSC1 UFSP1 ZNF34	250 interacting genes: A1CF ABHD17A ACTN3 AKAP17A AQP1 ARID5A ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf109 C1orf216 C2CD6 C4orf45 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCDC185 CCDC187 CCDC198 CCHCR1 CD40 CDC20 CDCA3 CDK18 CDKN1A CDKN2B CFLAR CHCHD3 CNTRL COX5B CRACR2A CRY2 CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 DUSP13 DUSP21 DUSP4 EBF2 EDAR EHHADH ENG ENKD1 EWSR1 FAM161A FAM161B FAM86C1P FBF1 FBXL18 FOSL2 GADD45GIP1 GATA1 GATA2 GATAD2B GCA GCM2 GEM GFI1B GIT2 GLIS3 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HELT HEY2 HGS HIVEP3 HMG20B HNRNPM HOXA1 HOXB5 HOXC8 HOXD12 IKBKB JOSD1 KANK2 KIAA1217 KIF1A KLHL38 KPNA2 KRT3 KRT75 LATS1 LCOR LIN37 LMNTD2 LNX1 LNX2 LRRN1 LTBR MACIR MAP3K14 MAP6 MAPRE2 MATR3 METTL17 MORN3 MOS MSGN1 MYEF2 MYOZ1 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PATZ1 PBX3 PDE4D PHF21A PIN1 PITX1 PITX2 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PPP1R32 PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RCOR3 RIIAD1 RIPK1 RIPK2 RIPOR3 RIPPLY1 RNF31 RTP5 SAMD11 SCAMP1 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHC3 SHFL SIK3 SLC25A48 SLC25A6 SNRNP25 SNW1 SOHLH1 SPATA46 SPG21 SPOP SPTAN1 SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TBC1D8 TBX18 TCEA2 TCF7L2 TCL1A TEAD4 TFAP2D TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSHZ2 TSSC4 USP2 USP7 UTP14C VEZF1 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZIC1 ZNF124 ZNF20 ZNF23 ZNF250 ZNF417 ZNF440 ZNF490 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF627 ZNF648 ZNF662 ZNF669 ZNF688 ZNF697 ZNF844
Entrez ID		6934	7185
HPRD ID		03751	03418
Ensembl ID		ENSG00000148737	ENSG00000056558
Uniprot IDs		A0A0A0MTL7 C6ZRJ7 C6ZRK1 C6ZRK2 C6ZRK5 Q5VVR7 Q6FHW4 Q9NQB0	Q13077
PDB IDs		1JDH 1JPW 2GL7	3M0D 5E1T 5H10
Enriched GO Terms of Interacting Partners?
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