TBX3 and CA8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		TBX3	CA8
Description		T-box transcription factor 3	carbonic anhydrase 8
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Blood Vessel Development In Utero Embryonic Development Cell Fate Specification Heart Looping Outflow Tract Morphogenesis Atrioventricular Bundle Cell Differentiation Cardiac Chamber Development Endocardial Cushion Formation Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Aging Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Animal Organ Morphogenesis Specification Of Animal Organ Position Stem Cell Population Maintenance Limbic System Development Male Genitalia Development Female Genitalia Development Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development Luteinizing Hormone Secretion Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Follicle-stimulating Hormone Secretion Mesoderm Morphogenesis Smooth Muscle Cell Differentiation Roof Of Mouth Development Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Placode Formation Cardiac Muscle Cell Fate Commitment Sinoatrial Node Cell Development Ureteric Peristalsis Cellular Senescence Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Stem Cell Proliferation	One-carbon Metabolic Process Phosphatidylinositol-mediated Signaling
Pathways
Drugs			Zonisamide
Diseases
GWAS		Atrial fibrillation ( 29892015) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21572416 21909110) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Breast cancer ( 29059683) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 26390057 28135244 19430479 27841878 29403010 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Facial morphology ( 31763980) FEV1 ( 30804560) Global electrical heterogeneity phenotypes ( 29622589) Heel bone mineral density ( 30598549 28869591) Hematological and biochemical traits ( 31902109) Hypertension ( 30487518) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic dilated cardiomyopathy ( 29495422) Ischemic stroke ( 29531354) Left ventricular QRS voltage ( 27195777) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longevity ( 30294719) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082 30804560) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Night sleep phenotypes ( 27126917) Nose morphology ( 29921221) Percent mammographic density ( 22532574) PR interval ( 30679814 30046033 32439900 20062060 25035420) PR segment duration ( 24850809) Prostate-specific antigen levels ( 28139693) QRS complex (12-leadsum) ( 27659466) QRS duration ( 30679814 27577874) Serum prostate-specific antigen levels ( 21160077) Stroke ( 29531354) Systolic blood pressure ( 27841878 29403010 27618452 25249183) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels in overweight individuals ( 25811787)	Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 28991256 25056061 29483656 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		14 interacting genes: CA8 CSF3 PFDN5 PLEKHF2 PRR20A PRR20B PRR20C PRR20D PRR20E SIRPA TLE5 TOLLIP UFSP1 ZNF34	14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3
Entrez ID		6926	767
HPRD ID		03373	00266
Ensembl ID		ENSG00000135111	ENSG00000178538
Uniprot IDs		A0A024RBL6 A0A024RBQ4 O15119	P35219
PDB IDs		1H6F	2W2J
Enriched GO Terms of Interacting Partners?
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