SPINT1 and AGR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPINT1	AGR3
Description		serine peptidase inhibitor, Kunitz type 1	anterior gradient 3, protein disulphide isomerase family member
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Endoplasmic Reticulum Intracellular Membrane-bounded Organelle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Dystroglycan Binding Protein Binding
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Biological_process Negative Regulation Of Cell Death
Pathways		MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Coffee consumption ( 31959922 29367735) Cutaneous malignant melanoma ( 32341527 26237428) Cutaneous squamous cell carcinoma ( 32041948) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Refractive error ( 32231278) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	36 interacting genes: AKT1 AP1B1 APC ASB10 BCAR3 BZW2 CASP8 CATSPER1 CD46 CGRRF1 CNNM3 DAG1 DESI1 EDA2R ERLIN1 ESR2 FXYD3 KRTAP11-1 LIME1 LSM1 LYPD3 MMGT1 NRM NTAQ1 NUP62 PDZK1IP1 PRAF2 PTPN1 SGTA SGTB SPINT1 TGFB1 TIMMDC1 TMEM14B UBQLN1 UBQLN2
Entrez ID		6692	155465
HPRD ID		05494	16545
Ensembl ID		ENSG00000166145	ENSG00000173467
Uniprot IDs		O43278	Q8TD06
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V	3PH9
Enriched GO Terms of Interacting Partners?
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