SNCA and STAMBP

Number of citations of the paper that reports this interaction (PubMedID 30021006)
6

Data Source:
BioGRID (enzymatic study)

		SNCA	STAMBP
Description		synuclein alpha	STAM binding protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Ribosome Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Inclusion Body Axon Growth Cone Synaptic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Neuronal Cell Body Terminal Bouton Axon Terminus Perinuclear Region Of Cytoplasm Postsynapse Supramolecular Fiber	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	SNARE Binding Magnesium Ion Binding Transcription Cis-regulatory Region Binding Actin Binding Protein Kinase Inhibitor Activity Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Microtubule Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Protein Domain Specific Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Phospholipase Binding Protein N-terminus Binding Tau Protein Binding Beta-tubulin Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity Dynein Complex Binding Cuprous Ion Binding	Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Receptor Recycling Positive Regulation Of Neurotransmitter Secretion Negative Regulation Of Protein Kinase Activity Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Membrane Organization Chemical Synaptic Transmission Aging Adult Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Regulation Of Transmembrane Transporter Activity Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation SNARE Complex Assembly Positive Regulation Of SNARE Complex Assembly Regulation Of Locomotion Dopamine Biosynthetic Process Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Positive Regulation Of Exocytosis Negative Regulation Of Dopamine Metabolic Process Behavioral Response To Cocaine Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Positive Regulation Of Inflammatory Response Synapse Organization Regulation Of Acyl-CoA Biosynthetic Process Protein Tetramerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Norepinephrine Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Regulation Of Neuron Death Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Desipramine Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Presynapse Assembly	Mitotic Cytokinesis Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination
Pathways		Amyloid fiber formation	Metalloprotease DUBs
Drugs		Resveratrol Copper
Diseases
GWAS		Anxiety ( 33859377) Blood protein levels ( 30072576 29875488) Dementia with Lewy bodies ( 29263008) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling nervous ( 29500382) Neurociticism ( 29500382) Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 25064009 32201043 31660654 27182965 28892059 22438815 28011712 20070850 21044948 24511991 21738487 32310270) Parkinson's disease (age of onset) ( 31660654 33884653 30957308) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to bupropion in depression ( 27622933)	Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 33031748 23093944)
Interacting Genes		128 interacting genes: A1BG ACTA1 ADAP2 ADRB2 AKT1 AMBRA1 ANXA6 APLP1 APOE APP ARHGAP15 ARPP19 ARSA BAD BAG5 BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 CHRM5 COL25A1 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CTSD CYCS DMTN DNAJC5 DOCK7 DYRK1A EEF1A1 EGFR EIF3G ELK1 ENC1 ENSA FBXL5 FGR FKBP4 FYN GABARAPL1 GAPDH GBA GRK1 GRK2 GRK5 GRK6 GSK3B H1-1 H1-2 HSD17B4 HSP90AA1 HSPB2 HSPB6 HSPB8 KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D MT-CO1 MT-CO3 NEDD4 NEDD4L PAK3 PARK7 PDE4DIP PDIA2 PELP1 PFDN2 PLCB2 PLD1 PLK1 PLK2 PLK3 PPP3CA PRDX1 PREP PRKCE PRKN PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPTIN4 SIAH2 SLC6A3 SMURF2 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI STAMBP SYK SYN1 TGM1 TH TOMM20 TOR1A TPPP TUBA1A UBB UBC UBE2D2 UBE2W USP2 USP47 USP7 USP8 YOD1 YWHAB YWHAE YWHAH ZRANB1	46 interacting genes: ALAS1 AMN APOBEC3A BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP3 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28
Entrez ID		6622	10617
HPRD ID		01227	05877
Ensembl ID		ENSG00000145335	ENSG00000124356
Uniprot IDs		H6UYS5 P37840	A0A140VK54 O95630
PDB IDs		1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ 7NCA 7NCG 7NCH 7NCI 7NCJ 7NCK	2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?
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