SMPD2 and CCN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMPD2	CCN1
Description		sphingomyelin phosphodiesterase 2	cellular communication network factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding Heparin Binding Extracellular Matrix Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Chemotaxis Cell Adhesion Signal Transduction Positive Regulation Of Phospholipase Activity Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Wound Healing, Spreading Of Cells Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Atrial Septum Morphogenesis Negative Regulation Of Cell Death Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process
Pathways		Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Height ( 18391951)	Appendicular lean mass ( 33097823)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	6 interacting genes: CDC42 ITGAV ITGB5 SFTPD SMPD2 UBQLN2
Entrez ID		6610	3491
HPRD ID		04608	09089
Ensembl ID		ENSG00000135587	ENSG00000142871
Uniprot IDs		O60906	O00622 Q6FI18
PDB IDs			4D0Z 4D11
Enriched GO Terms of Interacting Partners?
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