SMARCD3 and RARB

Number of citations of the paper that reports this interaction (PubMedID 17363140)
22

Data Source:
BioGRID (pull down)

		SMARCD3	RARB
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	retinoic acid receptor beta
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex NpBAF Complex NBAF Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Transcription Factor Binding Nuclear Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Zinc Ion Binding Protein-containing Complex Binding Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Secondary Heart Field Specification Cardiac Right Ventricle Formation Neural Retina Development Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Muscle Cell Differentiation Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Glandular Epithelial Cell Development Growth Plate Cartilage Development Signal Transduction Negative Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Striatum Development Neurogenesis Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Neural Precursor Cell Proliferation
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Cytoprotection by HMOX1 Heme signaling	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550 Trifarotene
Diseases
GWAS		Eyebrow thickness ( 26926045) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG glycosylation ( 23382691) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Multiple myeloma ( 27363682) Red blood cell count ( 32888494)	Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Airflow obstruction ( 22837378) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Apolipoprotein A1 levels ( 32203549) Asthma ( 29273806) Bell's palsy ( 33602968) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Calcium levels ( 25972035) Carotid intima media thickness in rheumatoid arthritis ( 30251476) Cataracts ( 34127677) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronotype ( 30696823) Coffee consumption ( 31046077) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Dentures ( 31235808) Dietary macronutrient intake ( 29988085) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 33627673 29891935) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29785010 31959993) Low susceptibility to hepatitis C infection ( 31206233) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Molybdenum levels ( 26025379) Mood instability ( 31168069) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity (extreme) ( 19553259) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Optic nerve head parameters (multi-trait analysis) ( 31798171) Peak expiratory flow ( 30804560) Platelet distribution width ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		20 interacting genes: ARHGAP1 CCNE1 ESR1 ESRRA FANCA JUN MAPK14 NR1H4 NR5A1 NR5A2 PBX1 PPARG RARA RARB RARG RORA RXRA SMARCC1 SREBF1 STARD13	22 interacting genes: ARID1A CCNDBP1 CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 PNRC1 PPARGC1A PRKD2 PSMC5 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1
Entrez ID		6604	5915
HPRD ID		03440	07183
Ensembl ID		ENSG00000082014	ENSG00000077092
Uniprot IDs		A0A090N8Z9 Q6STE5	F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5
PDB IDs			1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ
Enriched GO Terms of Interacting Partners?
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