ZBTB10 and FUT8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZBTB10	FUT8
Description		zinc finger and BTB domain containing 10	fucosyltransferase 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Membrane Golgi Cisterna Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Metal Ion Binding	Protein Binding Glycoprotein 6-alpha-L-fucosyltransferase Activity SH3 Domain Binding Alpha-(1->6)-fucosyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	In Utero Embryonic Development Protein N-linked Glycosylation N-glycan Processing Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Oligosaccharide Biosynthetic Process Regulation Of Gene Expression Cell Migration Protein N-linked Glycosylation Via Asparagine Viral Protein Processing Protein Glycosylation In Golgi N-glycan Fucosylation L-fucose Catabolic Process Receptor Metabolic Process GDP-L-fucose Metabolic Process Regulation Of Cellular Response To Oxidative Stress
Pathways			Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 22197932 26482879) Basal cell carcinoma ( 33549134 27539887) Body mass index ( 28892062 30271922 25673413) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hypothyroidism ( 22493691) Late-onset myasthenia gravis ( 26562150) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Self-reported allergy ( 23817569) Self-reported risk-taking behaviour ( 30271922) Sex hormone-binding globulin levels ( 22829776) Urinary albumin-to-creatinine ratio ( 31511532)	Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cirrhosis (alcohol related) ( 32853455) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29083408) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG monosialylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Ischemic stroke ( 26732560) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis--Brain Glutamate Levels ( 20802204) N-glycan levels ( 21908519 21203500 31163085) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Systemising ( 31508503) Verbal-numerical reasoning ( 27046643)
Interacting Genes		20 interacting genes: CDC7 CEP19 DCX DDX6 EHHADH FUT8 HRAS LSM4 MAGOHB MOB3C MORF4L1 MORF4L2 MYO15B PACRGL PHF1 RBM41 RNF8 USP20 UTP25 ZNF417	3 interacting genes: CKB FBXO7 ZBTB10
Entrez ID		65986	2530
HPRD ID		15689	03994
Ensembl ID		ENSG00000205189	ENSG00000033170
Uniprot IDs		Q96DT7 Q9H9H3	A8K8P8 Q546E0 Q9BYC5
PDB IDs			2DE0 6VLD 6VLE 6X5H 6X5R 6X5S 6X5T 6X5U
Enriched GO Terms of Interacting Partners?
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