SLC18A1 and TFRC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC18A1	TFRC
Description		solute carrier family 18 member A1	transferrin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Synaptic Vesicle Membrane Terminal Bouton Clathrin-sculpted Monoamine Transport Vesicle Membrane	Extracellular Region Extracellular Space Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle Extracellular Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Serotonin:sodium Symporter Activity Monoamine Transmembrane Transporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Metalloexopeptidase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Xenobiotic Transport Serotonin Uptake Transmembrane Transport	Regulation Of Cell Growth Positive Regulation Of Protein Phosphorylation Proteolysis Iron Ion Transport Cellular Iron Ion Homeostasis Positive Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Positive Regulation Of Peptidyl-serine Phosphorylation Transferrin Transport Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Bone Resorption Positive Regulation Of Isotype Switching Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Xenobiotic Stimulus Transport Across Blood-brain Barrier Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor
Pathways		Na+/Cl- dependent neurotransmitter transporters	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Transferrin endocytosis and recycling RND2 GTPase cycle RND1 GTPase cycle
Drugs		Reserpine Norepinephrine Ephedra sinica root MMDA Metamfetamine	Iron Ferrous sulfate anhydrous Ferric cation Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Tetraferric tricitrate decahydrate Ferric derisomaltose
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cholesterol ( 31902109) Coronary artery disease ( 30104761) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertriglyceridemia ( 23505323) Major depressive disorder (broad) ( 20038947) Metabolic syndrome ( 30382898 31589552) Persistent hepatitis B virus infection ( 27244555) Pulse pressure ( 27841878) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 18193046 24886709)	Asthma ( 31959851 30929738) Asthma (adult onset) ( 30929738) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) Mean corpuscular hemoglobin ( 32888494 28453575 20139978 27863252 19862010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 28453575 20139978 27863252 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 32499647)
Interacting Genes		61 interacting genes: AGTRAP ANKRD46 APOL2 BRICD5 C2CD2L CCL4 CCL4L2 CNIH1 COL4A5 CTSA CXCL16 CYB561D2 FAM3C FCER1G FXYD3 GIMAP1 GJB2 GPR151 LAT MALL MFSD6 MGAM MIP MS4A1 MS4A13 NEU1 NRM OLFM4 ORMDL1 PEX16 PLP1 PLP2 PMP22 PNLIPRP1 PPP3CC RPRM SLC30A2 SLC30A8 SLC35B4 SLC35G1 SLC38A7 SLC39A2 SMCO4 SMIM1 STX2 STX8 TFRC TMEM120B TMEM128 TMEM14A TMEM14B TMEM203 TMEM218 TMEM239 TMEM42 TMEM60 TMEM65 TMEM86A VAMP5 YIPF4 YIPF6	31 interacting genes: ACAP1 AQP6 ARL13B ASGR2 B4GALT1 C1orf159 CD247 CD4 CREB3L1 FAM209A FAM210B GABARAP GET1 GPR152 HFE HIBADH LHFPL5 LMNA MFF MGST3 PAGE1 RAB5B RAB8A RANBP9 RASSF3 RELL2 RMDN3 SGTA SLC10A1 SLC18A1 TF
Entrez ID		6570	7037
HPRD ID		01897	01812
Ensembl ID		ENSG00000036565	ENSG00000072274
Uniprot IDs		P54219 Q96GL6	A8K6Q8 B7Z2I6 G3V0E5 P02786 Q7Z3E0
PDB IDs			1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I 6OKD 6W3H 6Y76
Enriched GO Terms of Interacting Partners?
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