WNK1 and PFKP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		WNK1	PFKP
Description		WNK lysine deficient protein kinase 1	phosphofructokinase, platelet
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein Serine Kinase Activity	6-phosphofructokinase Activity Protein Binding ATP Binding AMP Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Monosaccharide Binding Fructose-6-phosphate Binding
	Biological Process	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Ion Transport Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Activation Of Protein Kinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Kinase Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Protein Autophosphorylation Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Cellular Response To Calcium Ion Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Fructose 6-phosphate Metabolic Process Fructose 1,6-bisphosphate Metabolic Process Canonical Glycolysis Cellular Response To Leukemia Inhibitory Factor
Pathways		Stimuli-sensing channels	Glycolysis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body size at age 10 ( 32376654) Disc degeneration (lumbar) ( 22993228) HDL cholesterol levels in HIV infection ( 33109212) Hippocampal volume in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Scalp hair shape ( 26926045) Subclinical trait of interstitial lung disease (percentage of high attenuation areas on CT scan) ( 28521775)
Interacting Genes		35 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	14 interacting genes: ACD AGO2 AKT1 DYNLL1 EGFR IL2RA KAT5 NUTF2 POT1 SUMO2 TERF1 TINF2 TRIM21 WNK1
Entrez ID		65125	5214
HPRD ID		05570	01384
Ensembl ID		ENSG00000060237	ENSG00000067057
Uniprot IDs		A5D8Z4 F5GWT4 Q9H4A3	A0A7I2V3Z0 B1APP6 Q01813
PDB IDs		4PWN 5TF9 5WDY 5WE8 6FBK	4RH3 4U1R 4WL0 4XYJ 4XYK 4XZ2
Enriched GO Terms of Interacting Partners?
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