CENPH and DCTN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		CENPH	DCTN2
Description		centromere protein H	dynactin subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Kinetochore Binding	Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Kinetochore Assembly Kinetochore Organization	Mitotic Spindle Organization Mitotic Metaphase Plate Congression Melanosome Transport Protein Localization To Centrosome
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NDC80 NUF2 NUP54 RASSF4 SPAG5 ZNF493 ZSCAN12	39 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR FXR1 FXR2 GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 OGT PAFAH1B1 RABGEF1 RINT1 RPGR SHANK3 SMARCD1 TSC1 TXLNB USHBP1 ZW10
Entrez ID		64946	10540
HPRD ID		12029	09568
Ensembl ID		ENSG00000153044	ENSG00000175203
Uniprot IDs		A0A0S2Z5T0 Q9H3R5	A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58
PDB IDs
Enriched GO Terms of Interacting Partners?
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