TUT1 and HMOX1

Number of citations of the paper that reports this interaction (PubMedID 21102410)
31

Data Source:
BioGRID (unspecified method)

		TUT1	HMOX1
Description		terminal uridylyl transferase 1, U6 snRNA-specific	heme oxygenase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol Nuclear Speck	Extracellular Space Nucleus Nucleoplasm Nucleolus Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity U6 SnRNA Binding Enzyme Binding Metal Ion Binding RNA Uridylyltransferase Activity RNA Adenylyltransferase Activity	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Structural Molecule Activity Protein Binding Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	MRNA Polyadenylation SnRNA Processing RNA 3'-end Processing U6 SnRNA 3'-end Processing Histone MRNA Catabolic Process Pre-mRNA Cleavage Required For Polyadenylation	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Cellular Response To Nutrient Positive Regulation Of Chemokine Production Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Liver Regeneration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways			Heme degradation Interleukin-4 and Interleukin-13 signaling The NLRP3 inflammasome Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1 Cytoprotection by HMOX1 Regulation of HMOX1 expression and activity Heme signaling
Drugs			NADH Formic acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Body shape index ( 34021172) Cerebrospinal fluid immune biomarker levels ( 32066700) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: CCDC86 HMOX1 IL32 KATNBL1 PIN1	44 interacting genes: AKT1 AQP6 ARL13B ASL BLVRB CD79A COQ9 CPLX4 CPSF1 CRB3 CREB3 CYB561 CYBRD1 ELOVL4 ELOVL5 ELOVL6 ERGIC3 FAM174A FAM209A FAM210B GPR152 JAGN1 KASH5 LMNA MSMO1 NOS1 PDGFB PDZK1IP1 POR POT1 PTGER4 SEC11C SLC16A7 SMO SNF8 STX1A TERF1 TEX33 TLCD4 TM4SF19 TMEM14B TMIE TUT1 ZNF132
Entrez ID		64852	3162
HPRD ID		15226	00782
Ensembl ID		ENSG00000149016	ENSG00000100292
Uniprot IDs		A0A0A8K9B1 F5H0R1 Q9H6E5	P09601 Q6FH11
PDB IDs		2E5G 5WU1 5WU2 5WU3 5WU4 5WU5 5WU6	1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA
Enriched GO Terms of Interacting Partners?
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