CERK and CRYBA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CERK	CRYBA1
Description		ceramide kinase	crystallin beta A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Lipid Kinase Activity Ceramide Kinase Activity NAD+ Kinase Activity Protein Binding ATP Binding Dihydroceramide Kinase Activity	Molecular_function Structural Constituent Of Eye Lens Protein Binding
	Biological Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Metabolic Process Phosphorylation Lipid Phosphorylation	Negative Regulation Of Cytokine Production Lens Development In Camera-type Eye Visual Perception Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Anoikis
Pathways		Glycosphingolipid metabolism
Drugs
Diseases
GWAS		Aseptic loosening in total joint arthroplasty ( 31791832) Triglyceride levels ( 30108155)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mean reticulocyte volume ( 32888494) Night sleep phenotypes ( 27126917)
Interacting Genes		21 interacting genes: ALAS1 APP CRYBA1 CYSRT1 KRT34 KRTAP1-1 KRTAP10-3 KRTAP11-1 KRTAP19-1 KRTAP19-6 KRTAP3-1 KRTAP3-2 KRTAP6-2 KRTAP9-2 MTUS2 NBPF19 NHLRC4 NOTCH2NLA OIP5 PLEKHF2 TRIM42	33 interacting genes: ARID5A BANF2 CELF6 CERK CHCHD2 CPD CRYAA CRYAB CRYBB1 CRYBB2 CRYBB3 CYSRT1 EVI2A EVI2B FBXO3 FOXH1 HOXC8 KLK10 KRTAP11-1 KRTAP13-2 KRTAP13-3 LASP1 NF1 NOXA1 OMG PLEKHF2 PROP1 RBPMS RHOXF2 SPRR1B TAF15 VAC14 YPEL3
Entrez ID		64781	1411
HPRD ID		09878	00429
Ensembl ID		ENSG00000100422	ENSG00000108255
Uniprot IDs		A0A024R4U8 Q8TCT0	P05813
PDB IDs
Enriched GO Terms of Interacting Partners?
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