SHMT2 and BABAM1

Number of citations of the paper that reports this interaction (PubMedID 31253574)
9

Data Source:
BioGRID (pull down)

		SHMT2	BABAM1
Description		serine hydroxymethyltransferase 2	BRISC and BRCA1 A complex member 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body BRCA1-A Complex BRISC Complex
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding	Protein Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration	Double-strand Break Repair Chromatin Organization Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination
Pathways		Metabolism of folate and pterines RHOG GTPase cycle	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)	Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Epithelial ovarian cancer ( 25581431) Mitochondrial DNA copy number ( 30704525)
Interacting Genes		28 interacting genes: ABRAXAS2 ACVR1B APP ARL6IP1 BABAM1 BABAM2 BRCC3 CAB39 CFTR CLEC2D CMTM5 COMMD6 CREB3 CSNK2B DUX4 ESR1 FBXO7 KASH5 KMT2D MAL2 NDRG1 NKD2 OGT PPARD PRKAG1 RND1 SCAF11 TUBA1C	9 interacting genes: AKT1 BABAM2 BRCA1 GATAD2A SHMT2 TERF2IP TNKS TRIM27 UBC
Entrez ID		6472	29086
HPRD ID		00717	13702
Ensembl ID		ENSG00000182199	ENSG00000105393
Uniprot IDs		A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06	A0A024R7L2 J3KQS6 Q9NWV8
PDB IDs		4PVF 5V7I 5X3V 6DK3 6H3C 6M5O 6QVG 6QVL 6R8F	6H3C
Enriched GO Terms of Interacting Partners?
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