MTMR14 and TIE1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		MTMR14	TIE1
Description		myotubularin related protein 14	tyrosine kinase with immunoglobulin like and EGF like domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Perinuclear Region Of Cytoplasm	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Macroautophagy Peptidyl-tyrosine Dephosphorylation	Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Positive Regulation Of Kinase Activity Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane
Drugs			Fostamatinib
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: APP ENO3 EPHA1 EPHA7 EPHB2 LTK OXNAD1 TIE1 TP53BP2	13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1
Entrez ID		64419	7075
HPRD ID		08654	02572
Ensembl ID		ENSG00000163719	ENSG00000066056
Uniprot IDs		Q8NCE2 Q8WYY9	B4DTW8 P35590
PDB IDs			5N06
Enriched GO Terms of Interacting Partners?
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