SCNN1B and HECW1

Number of citations of the paper that reports this interaction (PubMedID 11244092)
46

Data Source:
BioGRID (far western blotting)

		SCNN1B	HECW1
Description		sodium channel epithelial 1 subunit beta	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Sodium Channel Complex Extracellular Exosome Plasma Membrane Protein Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Sodium Ion Transport Excretion Response To Xenobiotic Stimulus Gene Expression Artery Smooth Muscle Contraction Response To Food Aldosterone Metabolic Process Erythrocyte Homeostasis Multicellular Organism Growth Sodium Ion Transmembrane Transport Epithelial Fluid Transport Multicellular Organismal Water Homeostasis Sensory Perception Of Taste Potassium Ion Homeostasis Sodium Ion Homeostasis Mucus Secretion Neutrophil-mediated Killing Of Bacterium Urea Homeostasis Cellular Response To Aldosterone	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Stimuli-sensing channels	Degradation of DVL
Drugs		Triamterene Amiloride
Diseases
GWAS		Kidney stones ( 31729369)	Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)
Interacting Genes		14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2	19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1
Entrez ID		6338	23072
HPRD ID		02861	11385
Ensembl ID		ENSG00000168447	ENSG00000002746
Uniprot IDs		B2R812 P51168	Q76N89
PDB IDs		6BQN 6WTH	3L4H
Enriched GO Terms of Interacting Partners?
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