SCN1B and NFASC

Number of citations of the paper that reports this interaction (PubMedID 11470829)
66

Data Source:
HPRD (in vivo)

		SCN1B	NFASC
Description		sodium voltage-gated channel beta subunit 1	neurofascin
Image
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Node Of Ranvier Perikaryon	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Paranodal Junction Node Of Ranvier Axon Initial Segment Schwann Cell Microvillus Ficolin-1-rich Granule Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential	Protein Binding Protein Domain Specific Binding
	Biological Process	Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Sodium Ion Transmembrane Transport Locomotion Response To Pyrethroid Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity	Cell Adhesion Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Myelination Synapse Organization Protein Localization To Plasma Membrane
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Interaction between L1 and Ankyrins Neurofascin interactions Neurofascin interactions Neutrophil degranulation
Drugs		Ranolazine Phenytoin Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases
GWAS		Metabolite levels ( 23823483) Serum albumin level ( 23022100)	Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576 29875488 28240269) Clozapine-induced agranulocytosis ( 25187353) Dental caries ( 23064961) Diisocyanate-induced asthma ( 25918132) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) General risk tolerance (MTAG) ( 30643258) High myopia ( 32428537) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Regular attendance at a religious group ( 29970889)
Interacting Genes		6 interacting genes: ADRA1A ANK3 C5AR2 F2RL1 NFASC SCN2B	12 interacting genes: ABI1 ABI2 ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR
Entrez ID		6324	23114
HPRD ID		02581	12372
Ensembl ID		ENSG00000105711	ENSG00000163531
Uniprot IDs		A0A1W2PR05 Q07699	B4DRH7 O94856
PDB IDs		6AGF 6J8G 6J8H 6J8I 6J8J	3P3Y 3P40
Enriched GO Terms of Interacting Partners?
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