SORT1 and NGF

Number of citations of the paper that reports this interaction (PubMedID 14985763)
311

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo, in vitro)

		SORT1	NGF
Description		sortilin 1	nerve growth factor
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Dendrite Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Golgi Lumen Cytosol Synaptic Vesicle Axon Dendrite Endosome Lumen
	Molecular Function	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Lipid Binding
	Biological Process	Ossification Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity Golgi To Lysosome Transport Positive Regulation Of Epithelial Cell Apoptotic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peripheral Nervous System Development Memory Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Endopeptidase Activity Nerve Development Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission
Pathways		Golgi Associated Vesicle Biogenesis	PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs			Clenbuterol RI 624 Polaprezinc
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 24097068 18193043 18193044 19060906 19060910 21347282 25961943 20686565) LDL cholesterol levels ( 28334899 26690388) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733 31969989) Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989) Metabolite levels ( 21909109) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Response to statins (LDL cholesterol change) ( 31969989) Response to statins (LDL cholesterol percent change) ( 31969989) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Total cholesterol levels ( 28334899)	Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Dysmenorrheic pain ( 27454463) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Obstetric antiphospholipid syndrome ( 28424481) Pain medicine use during menstruation ( 29855537) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Red blood cell count ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878)
Interacting Genes		17 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTF3 NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF	11 interacting genes: A2M CRYAB ITGA9 ITGB1 LRP1 MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		6272	4803
HPRD ID		03910	08874
Ensembl ID		ENSG00000134243	ENSG00000134259
Uniprot IDs		Q99523	A0A346FYQ1 P01138
PDB IDs		3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H	1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7
Enriched GO Terms of Interacting Partners?
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