RRM1 and CUZD1

		RRM1	CUZD1
Description		ribonucleotide reductase catalytic subunit M1	CUB and zona pellucida like domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Membrane Integral Component Of Membrane Zymogen Granule Membrane
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye	Cell Cycle Cell Adhesion Trypsinogen Activation Cell Division
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		22 interacting genes: BMI1 CDC42 CUZD1 LRIF1 NUP98 PPP1CC PSMD13 RGS4 RNF2 RNH1 RRM2 RRM2B SH2D3A SIRPA SLC22A18 SLC22A18AS SPINK1 STIM1 SUMO2 YWHAG ZFPM2 ZNF655	2 interacting genes: PTPN6 RRM1
Entrez ID		6240	50624
HPRD ID		01588	06476
Ensembl ID		ENSG00000167325	ENSG00000138161
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	Q86UP6
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?
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