RPS15 and G2E3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		RPS15	G2E3
Description		ribosomal protein S15	G2/M-phase specific E3 ubiquitin protein ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Focal Adhesion Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse	Nucleus Nucleolus Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Ribosomal Small Subunit Assembly Ribosomal Small Subunit Export From Nucleus Osteoblast Differentiation Cytoplasmic Translation RRNA Processing Translation Ribosomal Small Subunit Biogenesis Liver Regeneration Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity	Apoptotic Process Protein Ubiquitination
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494)	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cognitive decline (age-related) ( 28078323)
Interacting Genes		13 interacting genes: CDC42 DUX4 ERCC6 G2E3 GSK3A GSK3B NAP1L1 PLA2G12A PTEN RAPGEF1 RPS4X SERINC3 UPF2	4 interacting genes: LST1 RPS15 TRIM54 WDR6
Entrez ID		6209	55632
HPRD ID		01613	13851
Ensembl ID		ENSG00000115268	ENSG00000092140
Uniprot IDs		K7ELC2 P62841	B4DL73 F5GX24 Q49AD9 Q7L622
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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