ROBO1 and SRGAP1

Number of citations of the paper that reports this interaction (PubMedID 11672528)
185

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ROBO1	SRGAP1
Description		roundabout guidance receptor 1	SLIT-ROBO Rho GTPase activating protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Cell Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Signal Transduction Negative Regulation Of Cell Migration Regulation Of Catalytic Activity
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs	Inactivation of CDC42 and RAC1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Schizophrenia ( 33169155 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920) Waist-hip index ( 34021172)	Bone erosion in rheumatoid arthritis ( 28512992) Cerebral microbleeds ( 31209788) Epithelial ovarian cancer ( 25134534) PR interval ( 32439900)
Interacting Genes		10 interacting genes: ABL1 MAGEB6 MAPK14 MYCBP ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	6 interacting genes: BMPR1B CDC42 FASLG RAC1 RHOA ROBO1
Entrez ID		6091	57522
HPRD ID		03890	09406
Ensembl ID		ENSG00000169855	ENSG00000196935
Uniprot IDs		Q1RMC8 Q9Y6N7	Q7Z6B7
PDB IDs		2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79
Enriched GO Terms of Interacting Partners?
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