BCL9 and PYGO2

Number of citations of the paper that reports this interaction (PubMedID 11955446)
208

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		BCL9	PYGO2
Description		BCL9 transcription coactivator	pygopus family PHD finger 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cis-Golgi Network Beta-catenin-TCF Complex	Nucleoplasm Beta-catenin-TCF Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Beta-catenin Binding	Chromatin Binding Protein Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding
	Biological Process	Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway	Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Roof Of Mouth Development Canonical Wnt Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Schizophrenia (negative symptoms) ( 23382809) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 25760438)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: CTNNB1 PYGO1 PYGO2 USP9X	7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP
Entrez ID		607	90780
HPRD ID		04000	06065
Ensembl ID		ENSG00000116128	ENSG00000163348
Uniprot IDs		A0A024QYY4 O00512 Q1JQ81	Q5T170 Q9BRQ0
PDB IDs		2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9	2XB1 4UP0 4UP5
Enriched GO Terms of Interacting Partners?
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