APOBEC3G and RNF7

Number of citations of the paper that reports this interaction (PubMedID 31253590)
13

Data Source:
BioGRID (enzymatic study)

		APOBEC3G	RNF7
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 3G	ring finger protein 7
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Apolipoprotein B MRNA Editing Enzyme Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding DCTP Deaminase Activity Identical Protein Binding Deoxycytidine Deaminase Activity	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Cytidine Deamination Negative Regulation Of Transposition Base Conversion Or Substitution Editing Cytidine To Uridine Editing Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Viral Process Defense Response To Virus DNA Cytosine Deamination DNA Demethylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Response To Redox State
Pathways			Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233)	Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		7 interacting genes: APOBEC3F APP ARIH2 HDAC6 PRKACA PTN RNF7	41 interacting genes: APOBEC3F APOBEC3G ASB11 BTRC CASP7 CBFB CDC34 CHFR CREBBP CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS ELOB ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2L3 UBE2M UBE2Q1
Entrez ID		60489	9616
HPRD ID		06172	04840
Ensembl ID		ENSG00000239713	ENSG00000114125
Uniprot IDs		Q9HC16	Q9UBF6
PDB IDs		2JYW 2KBO 2KEM 3E1U 3IQS 3IR2 3V4J 3V4K 4ROV 4ROW 5ZVA 5ZVB 6BUX 6BWY 6K3J 6K3K	2ECL
Enriched GO Terms of Interacting Partners?
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