BRD2 and E2F2

Number of citations of the paper that reports this interaction (PubMedID 10965846)
78

Data Source:
HPRD (in vivo)

		BRD2	E2F2
Description		bromodomain containing 2	E2F transcription factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Chromatin Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Binding Lysine-acetylated Histone Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Neural Tube Closure Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Spermatogenesis	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process
Pathways		RUNX3 regulates p14-ARF	Oxidative Stress Induced Senescence Oncogene Induced Senescence CDC6 association with the ORC:origin complex Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 28008999) Feeling nervous ( 29500382) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28008999) Ulcerative colitis ( 28008999)	Eosinophil counts ( 32888494 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		18 interacting genes: CDC42EP4 CLCN2 DDR1 E2F1 E2F2 ECEL1 H2BC21 H2BU1 H4-16 HLA-DQA1 HOXC6 PHF1 PRNP PSMB9 RAC2 SPOP TBP TOP1	22 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CD48 CDK3 FHL2 GIT2 GNB5 GRB2 HPCA KMT5A MUC1 RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1
Entrez ID		6046	1870
HPRD ID		03326	02692
Ensembl ID		ENSG00000204256	ENSG00000007968
Uniprot IDs		A0A024RCR5 A0A1U9X7A8 P25440 X5CF57	Q14209
PDB IDs		1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH 4J1P 4MR5 4MR6 4QEU 4QEV 4QEW 4UYF 4UYG 4UYH 5BT5 5DFB 5DFC 5DFD 5DW1 5EK9 5HEL 5HEM 5HEN 5HFQ 5IBN 5IG6 5N2L 5O38 5O39 5O3A 5O3B 5O3C 5O3D 5O3E 5O3F 5O3G 5O3H 5O3I 5U5S 5U6V 5UEW 5XHE 5XHK 6CUI 6DB0 6DBC 6DDI 6DDJ 6E6J 6FFE 6FFF 6FFG 6I80 6I81 6JKE 6K04 6K05 6MO7 6MO8 6MO9 6MOA 6ONY 6SWO 6SWP 6TQ1 6TQ2 6U61 6U71 6U8H 6ULQ 6ULT 6VIY 6YTM 6Z7F 6Z8P 6ZB0 6ZB1 6ZB2 7JX7	1N4M
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?