AVPI1 and PRKACB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AVPI1	PRKACB
Description		arginine vasopressin induced 1	protein kinase cAMP-activated catalytic subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Protein Serine Kinase Activity
	Biological Process	Cell Cycle Positive Regulation Of MAPK Cascade	Neural Tube Closure Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Protein Kinase A Signaling High-density Lipoprotein Particle Assembly Negative Regulation Of Meiotic Cell Cycle Regulation Of Protein Processing Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways			PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Phosphonothreonine Fostamatinib
Diseases
GWAS			Breast cancer (male) ( 23001122) Metabolite levels ( 23823483)
Interacting Genes		34 interacting genes: APP C1orf109 CABP2 CDCA7L CYSRT1 DGCR6L EMD ENKD1 GOLGA6L9 IKBKG KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP4-2 LMO3 LONRF1 MDFI MKRN3 PHF1 PICK1 POLR1C PPP1R16A PRKAA2 PRKACA PRKACB RIPPLY1 RIPPLY2 SCNM1	15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73
Entrez ID		60370	5567
HPRD ID		16530	01482
Ensembl ID		ENSG00000119986	ENSG00000142875
Uniprot IDs		Q5T686	A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694
PDB IDs
Enriched GO Terms of Interacting Partners?
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