RGS12 and NPY2R

Number of citations of the paper that reports this interaction (PubMedID 9651375)
57

Data Source:
HPRD (in vitro)

		RGS12	NPY2R
Description		regulator of G protein signaling 12	neuropeptide Y receptor Y2
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cilium Non-motile Cilium
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Peptide YY Receptor Activity Neuropeptide Y Receptor Activity Calcium Channel Regulator Activity Protein Binding Signaling Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Catalytic Activity	Behavioral Fear Response Positive Regulation Of Peptide Secretion Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Nitric Oxide Mediated Signal Transduction Aging Locomotory Behavior Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Nervous System Process Positive Regulation Of Dopamine Secretion Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Secretion Negative Regulation Of Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Feeding Behavior
Pathways		G alpha (i) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Cysteamine Peptide YY (3-36) Obinepitide
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin level ( 29403010) Total cholesterol levels ( 29403010 33339817) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Premature menopause in childhood cancer survivors ( 29432556)
Interacting Genes		17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG	4 interacting genes: NPY PYY RGS12 TRARG1
Entrez ID		6002	4887
HPRD ID		03943	01216
Ensembl ID		ENSG00000159788	ENSG00000185149
Uniprot IDs		O14924	P49146
PDB IDs		2EBZ 2KV8	2IK3
Enriched GO Terms of Interacting Partners?
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