RGS1 and MAP3K12

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RGS1	MAP3K12
Description		regulator of G protein signaling 1	mitogen-activated protein kinase kinase kinase 12
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Leukotriene Signaling Pathway	Protein Phosphorylation JNK Cascade Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs			Fostamatinib
Diseases
GWAS		Celiac disease ( 22057235 20190752 30572963 18311140) Multiple sclerosis ( 24076602 21833088 27386562) Systemic lupus erythematosus ( 33536424 28714469) Type 1 diabetes ( 34127860)	Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 PRKD1 TSC22D1 UTP14A	16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1
Entrez ID		5996	7786
HPRD ID		15968	02709
Ensembl ID		ENSG00000090104	ENSG00000139625
Uniprot IDs		Q08116	A0A024RAY5 Q12852
PDB IDs		2BV1 2GTP	5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2
Enriched GO Terms of Interacting Partners?
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