RFC3 and RAD17

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RFC3	RAD17
Description		replication factor C subunit 3	RAD17 checkpoint clamp loader component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity	Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair DNA Duplex Unwinding Response To Organophosphorus Positive Regulation Of DNA-directed DNA Polymerase Activity	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Colorectal cancer or advanced adenoma ( 30510241) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obesity-related traits ( 23251661)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		13 interacting genes: ANKRD40 ARFGAP1 CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4	16 interacting genes: ATM ATR F2RL1 HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20
Entrez ID		5983	5884
HPRD ID		02676	09124
Ensembl ID		ENSG00000133119	ENSG00000152942
Uniprot IDs		A0A024RDQ8 P40938	O75943
PDB IDs		6VVO
Enriched GO Terms of Interacting Partners?
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