RASGRF2 and AKTIP

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		RASGRF2	AKTIP
Description		Ras protein specific guanine nucleotide releasing factor 2	AKT interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Nucleus Cytosol Plasma Membrane FHF Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calmodulin Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Small GTPase Mediated Signal Transduction Response To Endoplasmic Reticulum Stress Regulation Of Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Long-term Synaptic Potentiation Regulation Of NMDA Receptor Activity	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Eating disorders ( 23568457) Eating disorders (purging via substances) ( 23568457) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mucinous adenocarcinoma in colorectal cancer ( 29942513) Orofacial clefts ( 22419666) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Statin-induced myopathy (severe) ( 31220337) Superior frontal gyrus grey matter volume ( 25335168)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 34021172 25673412) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		5 interacting genes: AKTIP CDC42 KRAS RAC1 RHOA	35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM32 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS41 ZNRF2
Entrez ID		5924	64400
HPRD ID		07588	07467
Ensembl ID		ENSG00000113319	ENSG00000166971
Uniprot IDs		A0A2X0SFL3 O14827 Q68DX5	A0A024R6S6 A0A024R6T5 Q9H8T0
PDB IDs
Enriched GO Terms of Interacting Partners?
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