RASGRF1 and GRIN2B

Number of citations of the paper that reports this interaction (PubMedID 14622581)
167

Data Source:
BioGRID (pull down)

		RASGRF1	GRIN2B
Description		Ras protein specific guanine nucleotide releasing factor 1	glutamate ionotropic receptor NMDA type subunit 2B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Cytoplasm Lysosome Late Endosome Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Neuron Projection Postsynaptic Membrane Synaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Protein Binding Zinc Ion Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Long-term Memory Cell Population Proliferation Neuron Projection Development Response To Endoplasmic Reticulum Stress Regulation Of Rac Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Activation Of GTPase Activity Regulation Of NMDA Receptor Activity	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Brain Development Learning Or Memory Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Response To Ethanol Regulation Of Synaptic Plasticity Protein Heterotetramerization Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Neuron Death Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade	EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Activated NTRK2 signals through FYN Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Haloperidol Acamprosate Donepezil Guaifenesin Felbamate Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Taurine Milnacipran EVT-101 Lumateperone Acetylcysteine Ketobemidone Gavestinel Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Esketamine Fluciclovine (18F)
Diseases
GWAS		Adult body size ( 32376654) Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) High myopia ( 32428537) Myopia ( 27182965) Pancreatic beta-cell glucose sensitivity ( 32944759) Refractive error ( 23396134 32231278 20835236) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Adventurousness ( 30643258) Aging (time to event) ( 21782286) Alzheimer's disease in hypertension ( 31055733) Anxiety ( 33859377) Brain structure (temporal lobe volume) ( 20197096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cognitive performance ( 19734545) Dietary fat liking ( 32516399) Egg allergy (parent-of-origin effect) ( 29489655) General risk tolerance (MTAG) ( 30643258) Height ( 31562340) Immune reponse to smallpox (secreted IL-2) ( 22610502) Keratoconus ( 33649486) Major depressive disorder ( 23377640) Opioid dependence (time to event) ( 34124712) Ovarian reserve ( 22116950) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653) Total ventricular volume ( 21116278) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		19 interacting genes: CEBPA EHD4 GRIN2B GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 TNK2 USP8 YWHAB YWHAE	46 interacting genes: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 EGFR EPHB2 ERBIN EXOC4 EXOC7 FYN GRIN1 GRIN2A GRIN3A IL16 LIN7A LIN7B MAGI3 MIB2 PATJ PIK3CA PLCG1 PRKCA PRKCB PRKCG PRKN PTPN11 RACK1 RASGRF1 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		5923	2904
HPRD ID		07362	00697
Ensembl ID		ENSG00000058335	ENSG00000273079
Uniprot IDs		A8K270 Q13972 Q8IUU5	Q13224
PDB IDs			1S11 1S2S 2IPV 5EWJ 5EWL 5EWM 6XBP 6XBX 6XDL 6XDU 6XOE 7KL0 7KL1 7KL2 7KL4
Enriched GO Terms of Interacting Partners?
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