RAP1A and RASA1

Number of citations of the paper that reports this interaction (PubMedID 2164710)
60

Data Source:
HPRD (in vivo)

		RAP1A	RASA1
Description		RAP1A, member of RAS oncogene family	RAS p21 protein activator 1
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Endosome Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Small GTPase Binding Protein-containing Complex Binding	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Microvillus Assembly Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Glucose Import Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways		Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874 32581322) High altitude adaptation ( 28373541) Lymphocyte counts ( 32888494) Osteoporosis-related phenotypes ( 20548944)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C	96 interacting genes: ABL1 AFAP1L2 ALK ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NRAS NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF366 ZNF579
Entrez ID		5906	5921
HPRD ID		01545	00745
Ensembl ID		ENSG00000116473	ENSG00000145715
Uniprot IDs		A8KAH9 P62834	P20936 Q59GK3
PDB IDs		1C1Y 1GUA 3KUC 4KVG	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY
Enriched GO Terms of Interacting Partners?
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