RAB27A and BACE2

		RAB27A	BACE2
Description		RAB27A, member RAS oncogene family	beta-secretase 2
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Lysosome Late Endosome Golgi Apparatus Cytosol Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Protein Targeting Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process
Pathways		Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)	Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)
Interacting Genes		29 interacting genes: ADRB2 APP BACE2 CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	11 interacting genes: ABCA8 ACVR2A APP DIP2A GGA1 GGA2 ICOSLG LTC4S POFUT2 RAB27A UBASH3A
Entrez ID		5873	25825
HPRD ID		04845	05744
Ensembl ID		ENSG00000069974	ENSG00000182240
Uniprot IDs		A2RU94 P51159	Q9Y5Z0
PDB IDs		6HUF	2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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