QARS1 and COG6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		QARS1	COG6
Description		glutaminyl-tRNA synthetase 1	component of oligomeric golgi complex 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex	Golgi Membrane Golgi Transport Complex Trans-Golgi Network Membrane
	Molecular Function	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway	Intra-Golgi Vesicle-mediated Transport Protein Transport Glycosylation
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS			Asthma ( 31959851 30929738 32296059) Asthma (adult onset) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Psoriasis ( 25903422 18369459) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		157 interacting genes: ACTN2 ANXA7 APP ASL B9D2 BIRC7 CALCOCO2 CCDC33 CDK4 CDKN1A CLTC COG6 CPNE3 CTBP2 DISC1 DNM2 DPPA4 DTX2 DUSP11 EDC3 EFHC2 ESS2 FAM118B FAM161A FAM83A GADD45A GPBP1 GSK3B GSTZ1 H2AX HES7 HMG20A HOXA1 IK IKZF1 IRF1 KCNE3 KLC3 KRT36 LAMTOR3 LGALS9B LGALS9C LNX1 LZTS1 LZTS2 MAP3K5 MCCD1 MESD MID2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15A MIR15B MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NAB2 NEBL NFKBID NLGN3 NOXA1 PICK1 PIK3R3 PIN1 PPP1R32 PRDM6 PRRC2A PTPN21 RARS1 REL RNF11 SF3B4 SHLD1 SLA SMAD9 SMN1 SORBS3 SP7 SPATC1L SPDYE4 SPRED2 STK3 TADA2A TCF12 TGM7 TK1 TLE5 TOPAZ1 TRAF2 TRAF4 TRIM27 TRIM35 TRIP13 TSC22D1 TTR USHBP1 VPS37B XIAP ZMYND12 ZRANB1	68 interacting genes: ARHGEF5 ATXN7 BAIAP2 BCL10 CCDC116 CCDC120 CCDC187 CCDC92 CCHCR1 CNN1 CNNM3 CSRP2 CUL5 DNM2 DOCK8 DTNB FAM110A FAM90A1 FANCG FNDC11 GAS8 GEM GOLGA2 GRAP2 IGFN1 KANK2 LGALS14 LMO4 MCM7 MFAP1 MRI1 NDUFA5 NEK6 NTAQ1 NUP58 OAS1 PLEKHA2 POM121 PPP1R18 PPP1R32 PSMA1 PSMB1 QARS1 RAB3IL1 RAB6B RSPH14 RTP5 RUNX1T1 SCNM1 SMARCD1 SNAI1 SNAP29 SNRPB SPG21 SYCP2L SYT17 TBC1D22B TMSB4X TSC1 TSGA10 TSHZ3 TSNAX TTC7B UFSP1 WASHC3 ZBTB16 ZFC3H1 ZNF417
Entrez ID		5859	57511
HPRD ID		07223	08445
Ensembl ID		ENSG00000172053	ENSG00000133103
Uniprot IDs		B7Z840 P47897	A0A024RDW5 A0A140VJG7 Q9Y2V7
PDB IDs		4R3Z 4YE6 4YE8 4YE9
Enriched GO Terms of Interacting Partners?
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