PTPRF and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 10777529)
16

Data Source:
HPRD (two hybrid, in vivo)

		PTPRF	PTPRA
Description		protein tyrosine phosphatase receptor type F	protein tyrosine phosphatase receptor type A
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse Integral Component Of Synaptic Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	Protein Phosphorylation Protein Dephosphorylation Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Modulation Of Chemical Synaptic Transmission Regulation Of Focal Adhesion Assembly
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444 33495439) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		68 interacting genes: ABCG1 ACAN ACAT1 ACTB ALDH1A1 ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INPP5B INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB LINC01587 MPL MYCBP NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B UROD VCAN YBX1 ZMPSTE24 ZNF512B	18 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GRB2 HSPB1 KCNA2 LINC00839 MBP POFUT1 PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		5792	5786
HPRD ID		01552	01476
Ensembl ID		ENSG00000142949	ENSG00000132670
Uniprot IDs		G1UI20 P10586	P18433
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW	6UZT
Enriched GO Terms of Interacting Partners?
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